Singh et. al. 2012
“The present report provides the first ever conclusive proof in support of apoptosis as a novel stratagem in
antifilarial drug designing and nanoscale silver as a valid lead in research on antifilarial therapeutics.
Effective microfilaricidal activity of nanosilver at relatively low concentrations as reported in this study,
with evidence of the induction of apoptosis in microfilariae, projects nanosilver as a potential drug adjuvant
against lymphatic filariasis. The much higher 50% lethal dose value of nanosilver compared to the complete
inhibitory concentration value reported in this study argues in favour of a safe therapeutic window of this
agent in its antifilarial efficacy.”
